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• DeVetta Holman Nash
• Vann Newkirk II
• Gene R. Nichol
• Herbert Nickens
• Trevor Noah
• Pedro Noguera
• President Barack Obama
• Soledad O'Brien
• Andrew Olshan
  Dr. Olshan has been at UNC for over 30 years and has taught in both the cancer epidemiology and reproductive, perinatal and pediatric programs. He was epidemiology department chair from 2006 to 2018.
• Michael O'Malley
• Abdel Omran
• Jean Orelien
• Tracy Orleans
  C. Tracy Orleans, PhD
• Bernice Otudeko
  Bernice Green Otudeko was the first African American woman to graduate from the UNC School of Public Health (Health Education, 1966). She was also the first woman to sing with the UNC Varsity Men's Glee Club and performed with the Club at the NY World's Fair in 1964.
• Henry Owl